Insulin/IGF signaling and discoidin domain receptors: An emerging functional connection
نویسندگان
چکیده
منابع مشابه
Collagen recognition and transmembrane signalling by discoidin domain receptors☆
The discoidin domain receptors, DDR1 and DDR2, are two closely related receptor tyrosine kinases that are activated by triple-helical collagen in a slow and sustained manner. The DDRs have important roles in embryo development and their dysregulation is associated with human diseases, such as fibrosis, arthritis and cancer. The extracellular region of DDRs consists of a collagen-binding discoid...
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The extracellular matrix critically controls cancer cell behavior by inducing several signaling pathways through cell membrane receptors. Besides conferring structural properties to tissues around the tumor, the extracellular matrix is able to regulate cell proliferation, survival, migration, and invasion. Among these receptors, the integrins family constitutes a major class of receptors that m...
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The discoidin domain receptors (DDRs) are receptor tyrosine kinases that recognize collagens as their ligands. DDRs display unique structural features and distinctive activation kinetics, which set them apart from other members of the kinase superfamily. DDRs regulate cell-collagen interactions in normal and pathological conditions and thus are emerging as major sensors of collagen matrices and...
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The human discoidin domain receptors (DDRs), DDR1 and DDR2, are a unique subfamily of receptor tyrosine kinase as they bind to and are activated by the extracellular matrix protein collagen. The DDRs are expressed widely and play an important role in cell-matrix interaction, cell adhesion, motility and proliferation. Several different collagen types activate the DDRs, and both DDRs bind only na...
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Discoidin Domain Receptors (DDRs) have recently emerged as non-integrin-type receptors for collagen. The two mammalian gene products Discoidin Domain Receptor 1 and -2 constitute a subfamily of tyrosine kinase receptors that are selectively expressed in a number of different cell types and organs. Upon collagen activation, DDRs regulate cell adhesion, proliferation and extracellular matrix remo...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2019
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2019.118522